In this paper we develop and estimate a multi-sector general equilibrium growth model of education and sector-occupation choices over the life cycle. The model incorporates the task-based approach by representing jobs in different sector-occupation pairs as different bundles of tasks, requiring specific skill sets of workers. Workers are born with heterogeneous endowments of skills that can be improved over time by schooling and on-the-job accumulation of human capital. We use data from several U.S. sources that allow us to estimate parameters that correspond to both the decision process of the individuals as well as the parameters that correspond to the production side of the economy. The estimated GE model allows us  (1) to quantify the winners and losers from recent technological changes, as well as (2) to conduct policy counterfactuals that take full account of the responses in the economy.